Interesting thread, I've been using TR for years now, very happy, however, a role change in the past month has led to TR as a tool - my tool of choice being under pressure.
I have a number of constraints - using windows, Lotus Notes to name two...TR still fits the needs I have, but as I do use Lotus Notes and I've found the massive increase of mail (3 fold) to process and track in my new role a serious challenge - given "cut n paste" is the only integration to LN and I do that at a summary level.
I'm not sure I want to invest time flirting with a new tool, but I know I am not as productive now...so an interesting period of reflection I face.
I see the roadmap a key ingredient to some decisions I must make.